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KMID : 0811720140180050425
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 5 p.425 ~ p.430
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H2 Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)
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Lee Sang-Eok
Kim Dae-Hoon
Kim Young-Chul
Han Joung-Ho
Choi Woong
Kim Chan-Hyung
Jeong Hye-Won
Park Seon-Mee
Yun Sei-Jin
Choi Song-Yi
Sung Ro-Hyun
Kim Young-Ho
Yoo Ra-Young
Park Hee-Sun
Kim Heon
Song Young-Jin
Xu Wen-Xie
Yun Hyo-Yung
Lee Sang-Jin
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Abstract
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This study was designed to examine the effects of histamine on gastric motility and its specific receptor in the circular smooth muscle of the human gastric corpus. Histamine mainly produced tonic relaxation in a concentration-dependent and reversible manner, although histamine enhanced contractility in a minor portion of tissues tested. Histamine-induced tonic relaxation was nerve-insensitive because pretreatment with nerve blockers cocktail (NBC) did not inhibit relaxation. Additionally, K+ channel blockers, such as tetraethylammonium (TEA), apamin (APA), and glibenclamide (Glib), had no effect. However, NG-nitro-L-arginine methyl ester (L-NAME) and 1H-(1,2,4)oxadiazolo (4,3-A) quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase (sGC), did inhibit histamine-induced tonic relaxation. In particular, histamine-induced tonic relaxation was converted to tonic contraction by pretreatment with L-NAME. Ranitidine, the H2 receptor blocker, inhibited histamine-induced tonic relaxation. These findings suggest that histamine produced relaxation in circular smooth muscle of human gastric smooth muscle through H2 receptor and NO/sGC pathways.
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KEYWORD
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Circular smooth muscle, Corpus, H2 receptors, Histamine, Human stomach, Nitric Oxide (NO), Relaxation
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